MyBioSource.com's AR Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The AR Antibody (Center) was generated using Androgen Receptor, AR, DHTR, HUMARA, and TFM as the antigen and it reacts with Human.
Description
The androgen receptor gene is more than 90 kb long and
codes for a protein that has 3 major functional domains: the
N-terminal domain, DNA-binding domain, and androgen-binding domain.
The protein functions as a steroid-hormone activated transcription
factor. Upon binding the hormone ligand, the receptor dissociates
from accessory proteins, translocates into the nucleus, dimerizes,
and then stimulates transcription of androgen responsive genes.
This gene contains 2 polymorphic trinucleotide repeat segments that
encode polyglutamine and polyglycine tracts in the N-terminal
transactivation domain of its protein. Expansion of the
polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy
disease). Mutations in this gene are also associated with complete
androgen insensitivity (CAIS). Two alternatively spliced variants
encoding distinct isoforms have been described. [provided by
RefSeq]